Akkermansia - The Gut's Unsung Hero

Even though it can be a bit creepy to think about our body being host to trillions of microorganisms, each playing a crucial role in maintaining our health and well-being. Among these tiny microbial inhabitants, one newly discovered strand stands out for its potential significance in not only gut health but also immunity and weight management. 

Akkermansia is a keystone bacteria that resides in the mucus layer of the intestines, primarily in the distal colon. It is an anaerobic organism meaning that it lives without any oxygen.  It was discovered relatively recently in 2004, but its importance is quickly gaining attention.

The Guardian of Gut Health

One of the most remarkable attributes of Akkermansia is its ability to promote a healthy gut and maintain the gut barrier.  To understand how it works, think of your gut lining as a picket fence and Akkermansia as the glue holding the planks together.   These planks and glue serve as a crucial defense mechanism against harmful pathogens and toxins. By bolstering the mucosal layer (the glue), Akkermansia helps prevent harmful substances from leaking into the bloodstream.  This reduces the risk of inflammation and associated diseases that come with a leaky gut barrier. 

Akkermansia and Metabolic Health

In addition to its role in protecting the gut barrier, Akkermansia has also been linked to metabolic health. Research suggests that individuals with higher levels of Akkermansia in their gut tend to have better metabolic profiles, including improved glucose metabolism and lipid levels. Furthermore, studies in animal models have shown that supplementation with Akkermansia can decrease obesity-related complications such as diabetes. The American Gut Project found an inverse relationship between Akkermansia levels and BMI.  Those with high levels of Akkermansia had lower BMI’s and vice versa.

Immune Booster

Another key health benefit of Akkernamsia involves how it interacts with the host's immune system. By modifying the immune responses it promotes the production of anti-inflammatory molecules which reduces the risk of inflammatory bowel diseases and other immune-related conditions.

Elevates Energy

Moreover, Akkermansia produces short-chain fatty acids (SCFAs), such as acetate and propionate, through the fermentation of dietary fibers. These SCFAs serve as food sources for the cells lining the intestine and exert various metabolic effects throughout the body, contributing to overall health and well-being.  Studies have even found that centennials have high levels of Akkermansia. 

The only way to know what your Akkermansia levels are is to have a stool test completed.  Typically these tests will provide you with additional microbiome levels that also work along with Akkermansia and provide synergistic effects.  

Join me this month as we continue to explore Akkermansia and its potential health implications.